The purpose of the current research was the impact of geographic policies and key indicators on countering ISIS in the regional relations of the Islamic Republic of Iran. The research method was applied research in terms of the purpose of the research, and it was a mixed exploratory research in terms of its descriptive nature and from the perspective of the variables. The statistical sample of the qualitative part of the research is experts and experts in charge of foreign relations, Takfiri groups and ISIS. 1401 are working in decision-making centers and research centers. In the quantitative part, 335 people were randomly selected from among the activists of foreign relations and regional terrorism. The analysis of the findings of the qualitative part was done based on theme analysis with Max Kyuda 10 software and the quantitative part was done based on the structural equation model based on Lisrel analysis software. The findings of the quantitative part confirmed all the qualitative parts based on the model of the structural equation model. Geopolitical and axis indicators with a coefficient of 0.170 have an effect on the influence of ISIS on the regional relations of the Islamic Republic.